I-81 is very scenic in general especially in Pennsylvania. Despite all the trucks, it still makes for a good drive, as it beats I-95 any day. I’ve never really had a problem with the truckers on 81, as I’m used to driving on ON-401 which is also full of 18 wheelers.

About 95, it’s full of tolls and traffic, and it’s a pretty boring drive. It’s only interesting because you get to pass through big cities but either than that it’s a waste.