Don't think you read clearly what I wrote. I said if there was no genetic redundancy or large swaths of intronic regions, any genetic insult would result in catastrophe.

I didn't say all, i said vast majority. I am well aware that there are epigenetic factors indirectly related to gene expression. What I'm saying is there is a quality over quantity argument in which a change in the right spot is what matters, not a raw number which is what is touted in these buzzword

this is a buzzword, plain and simple. It takes one nucleotide switch to go from perfectly healthy to sickle cell disease. The vast majority of genetic information is nonsense on purpose. if every line of genetic code mattered, any genetic insult would result in catastrophic change.