cgarcia123

cgarcia123 t1_j8a1ysx wrote

Reply to Metformin regulates myoblast differentiation through an AMPK-dependent mechanism (Feb 2023) by basmwklz

I (m50) take half a gram extended release metformin daily, for longevity, for one year now. I always wonder if it will affect my muscles... it did make me B12 deficient, I was getting peripheral neuropathy (pins and needles in hands and feet) after one year, but taking a B12 supplement fixed that. I don't see any problems with my muscles, probably because I started lifting weights around the same time.

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cgarcia123 t1_j6rll2s wrote

Reply to The antidiabetic drug metformin aids bacteria in hijacking vitamin B12 from the environment through RcdA (Jan 2023) by basmwklz

I was taking half a gram of extended release metformin daily, for longevity, for about a year, until I started feeling pins and needles (peripheral neuropathy) in my hands and feet. I then remembered I had read about metformin and B12 deficiency, and I immediately stopped it and started on a B12 supplement. Less than 2 weeks later, the pins and needles were gone.

Now I'm taking it again as my glucose levels went up (to 112 mg/dL), but with the B12 supplement, and I plan to measure my B12 in two months time.

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cgarcia123 t1_izfihxv wrote

Reply to comment by uglylittle in Adopting and maintaining a healthy lifestyle might prevent up to 60% of inflammatory bowel disease (IBD) cases. Diagnoses of IBD have been increasing globally, the study authors noted, with the condition currently affecting around 1.3 million adults in Europe by Wagamaga

You can do this with any yogurt machine, but it's important to be able to get 37C with some accuracy. A sous vide stick in a water bath and some glass jars is a good way to do it, and you can make a lot at the same time. It can take 16 to 24 hours for the milk to curdle.

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cgarcia123 t1_iz9eid5 wrote

Reply to comment by Weird-Fox-4036 in Adopting and maintaining a healthy lifestyle might prevent up to 60% of inflammatory bowel disease (IBD) cases. Diagnoses of IBD have been increasing globally, the study authors noted, with the condition currently affecting around 1.3 million adults in Europe by Wagamaga

My IBD like gastric problems stopped 2 years ago when I started making (and eating) my own yogurt with the L. Reuteri probiotic. It's basically about using L. Reuteri capsules as a yogurt starter (look up youtube videos), and it's fun if anything. The yogurt this makes is more like cottage cheese but still quite tasty. Nowadays I usually start my yogurt with a 10 to 1 mix of L.Reuteri and normal yogurt, so the end result looks and tastes almost like store bought, but certainly contains a lot of L. Reuteri.

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