What I understand from some other research is that when these peripheral nerves become sensitized they spontaneous sends afferent signaling to the spinal cord - > brain without any external stimuli. This sustained signaling drives central sensitization. The idea is that central nervous system plasticity allows the reversal from central sensitization to the norm if these external stimuli reinforcing the [pain/damage/harm] are removed, especially since no actual sustained damage to the tissues is present.

I also educate my patients on the benefits of prolonged fasting, with the potential "repair" of peripheral nerves, spinal cord, etc. via autophagy. There is definitely research out there using mouse subjects and I wish more research funds would go towards this end but fasting isn't sexy more is its profitable.

The combo of fasting and capsaicin seem to provide the best outcomes.

The prior study that I read about used 8% patches so they had to anesthetize the area prior to application. The over the counter roll on from CVS is 0.15% and that burns hot enough.

The interesting thing is that I learned about this from a similar study probably about 6-7 years ago. Capsaicin damages the mitochondria in sensitized nerve cells (which are currently dysfunctional due to sending information to the brain that is incorrect). After the capsaicin application, the nerve cells first retract to some degree from the tissue they're inervating (such as the skin). Eventually those nerve cells regrow but apparently without dysfunctional signaling. I work in health care and I'm always looking for options to help my patients, especially those with chronic pain. I've never found a practitioner that utilized the capsaicin approach. If any, I would expect physiatrists to be the most open-minded to utilize this as a treatment option.

Edit.

This may be the study: https://openaccesspub.org/article/549/ijp-17-1581.pdf

Cool. I'll have to try that one out.

That's good news. I developed a wheat allergy in the last few years. [While I'm still technically undiagnosed the sxs are obvious soon after eating anything with wheat - nasal congestion, tingling in UEs and LEs, itching/burning skin, occasional diarrhea, malaise, you name it.] The more gluten-free options, the better. On a side note, Freschetta's gluten free pizza is the best. It's pricy but even my kids who do not like anything gluten-free can't tell the difference.

Worst customer service. Will never try to be competitive and lie to you. Only when you're no longer a customer will they try to work with you. Unfortunately I'm stuck with them for internet.

I used to be jittery when drinking coffee but my body has acclimated to it over the years so it's not much of an issue unless I'm taking a second cup soon after the first. L-Theanine was helpful to get the benefits of the caffeine without the jitters.

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"Caffeine was found to mainly improve performance on demanding long-duration cognitive tasks and self-reported alertness, arousal, and vigor. Significant effects already occurred at low doses of 40 mg. L-theanine alone improved self-reported relaxation, tension, and calmness starting at 200 mg. L-theanine and caffeine combined were found to particularly improve performance in attention-switching tasks and alertness, but to a lesser extent than caffeine alone. No conclusive evidence relating to effects induced by EGCG could be given since the amount of intervention studies was limited. These studies provided reliable evidence showing that L-theanine and caffeine have clear beneficial effects on sustained attention, memory, and suppression of distraction. Moreover, L-theanine was found to lead to relaxation by reducing caffeine induced arousal."

Since the big guns are doing it companies have more cover to do the same.

Healthcare management is profitable; prevention, not as much.

Current evidence suggest that fasting [intemittent or otherwise] with exercises will result in the same.