Cheddarific OP t1_is4bz8n wrote on October 13, 2022 at 5:13 AM

Reply to comment by fraktall in Why do solid tumor oncology clinical trials commonly use transcriptomics instead of measuring specific protein biomarkers? by Cheddarific

Interesting point about mechanisms of tumor behavior.

Cheddarific OP t1_is4buvh wrote on October 13, 2022 at 5:11 AM

Reply to comment by bio_med_guy in Why do solid tumor oncology clinical trials commonly use transcriptomics instead of measuring specific protein biomarkers? by Cheddarific

Transcriptome is undoubtedly fascinating in oncology, but the real question is how that translates into actual proteins, right? Like measuring the amount of time each student studies each textbook page for a test rather than capturing the actual results of the test; you get more data one way, but the data you really want is the smaller set, right?

Cheddarific OP t1_is4bjnj wrote on October 13, 2022 at 5:08 AM

Reply to comment by marouane53 in Why do solid tumor oncology clinical trials commonly use transcriptomics instead of measuring specific protein biomarkers? by Cheddarific

I like this response. Your first point resonates with me, but on the second point: given the cost of clinical trials and the small number of patients in oncology trials in particular, is the cost difference really so extreme?