One of the biggest issues with these papers is how early they start treating tumors - 7 days after graftment?

For these tumor models, you implant the cells on the back of the mice, and they need time to grow and form an actual robust tumor. 7 days is such little time to do all the things a tumor needs to do: teach the immune system to support it/help it, get blood vessels, build strong local environment to support it etc

7 days is not a great starting point… very early … rather see at least 12-14 days… for at least a more accurate model.

Not just a problem for this paper, problem around the field of cancer models in mice - people start early to make the effect look better.