Abstract highlights:

• In recent years, more and more evidence has proved that insulin regulates various functions of the brain.
• The hippocampus, one of the earliest brain regions affected by AD, is widely distributed with insulin receptors.
  • Studies have shown that type 2 diabetes mellitus, characterized by insulin resistance, is closely related to AD, which has drawn extensive attention to the relationship between hippocampal insulin signaling and AD.
• We also highlight the molecular link between hippocampal insulin resistance and AD and provide a theoretical basis for finding new therapeutic targets for AD in clinical practice.
• As a common link between T2DM and AD, in recent years, insulin resistance has been shown to contribute directly or indirectly to the progression of AD.