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rdizzy1223 t1_j9am8x9 wrote

Reply to comment by cjankowski in Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression (Feb 2023) by basmwklz

That isn't all it means, it means it needs to be administered via IV, it will not reach blood serum levels high enough if you take it orally, regardless of how much you take, you are just wasting it.

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cjankowski t1_j9atjki wrote

That isn’t inherent to the term (which also applies to cell culture studies) - pharmacologic ascorbate typically just means > 1 mM, which yes is only possible in human serum via IV

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