If it was a deathmatch, John Wick, easily. Especially if "whatever else is readily available in the room" can be used as a weapon. His combat versatility is on another level. He killed a dude with a fucking book ffs.

Between Jason Bourne and Ethan Hunt, I'd give it to Bourne. Ethan Hunt isn't really that great at hand to hand combat. His victories have largely come down to having an assist and/or being in the right place at the right time. He's otherwise fairly easily outmatched in direct combat. If this were a car chase battle though, he'd probably be in very close contention with John Wick, if not the winner.