Hidden_Armadillo t1_j7dfal8 wrote on February 5, 2023 at 11:46 PM

Reply to comment by CrazyisNSFW in Why do some allergies get worse over time and some better? And how does allergen desensitivity work without making the reaction worse? by DontDoDrugs316

Can this work with auto immune reaction responses such as celiac/gluten sensitivity?

Indemnity4 t1_j7dldsx wrote on February 6, 2023 at 12:31 AM

Non-celiac gluten sensitivity - Yes. Allergen specific immunotherapy. You wait 1-2 years on a gluten-free (or close enough) diet then slowly start to re-introduce low amounts of gluten.

Celiac - no. Studies trying antigen-specific immunotheraphy have all failed. Those people are usually missing an important gene in their DNA - difference from above is it was never working, not that it went bad over time and needs help recovering. Most future therapies are targeting the immune system response itself and silencing or inhibiting some part of the process.