Odds are in such a scenario you starve to death when your mini biome has some minor issue that disturbs the balance and ends up killing some crucial part of the system. Assuming all life is also dead outside your hab, you are dead.

If it's something that kills animals but not plants/fungi then maybe you'd have options, but it's still a massively complex system that you are trying to keep stable.

Maybe a system of many different but self-contained habs would have more resiliency. If you lose some component to a blight then maybe the other hab has some different strain that is unaffected.