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walruswes t1_iwhni08 wrote

Reply to comment by technofuture8 in World’s first stem cell treatment for spina bifida delivered during fetal surgery, in California. Three babies have been born after receiving the world’s first spina bifida treatment combining surgery with stem cells. by technofuture8

Do they use the placenta from the “patient” or use the placenta from elsewhere?

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technofuture8 OP t1_iwho4uu wrote

They used a placenta for the mesenchymal stem cells from a donor. MSCs don't have to be donor matched actually. In fact I could take mesenchymal stem cells (MSCs) from out of your bone marrow or belly fat and multiply the MSCs in a bio-reactor and then inject them into my body and there would be no immune rejection, I'd be fine.

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visualtim t1_iwjkqhp wrote

Not true; there's still host vs graft for most allogeneic transplants. Stem cells may evade the immune system for a couple of weeks, but that's it.

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technofuture8 OP t1_ixv9prn wrote

Did you know that mesenchymal stem cells are currently going through clinical trials for graft vs host disease? MSCs can literally modulate the immune system. This company right here is pioneering MSCs created from induced pluripotent stem cells and they've already conducted a phase 1 trial for graft vs host disease using their IPSC derived MSCs, and the results were amazing. At the two year mark 60% of the patients who received the MSCs were still alive, compared to, usually only 17% would be still be alive when treated with the standard of care.

https://www.cynata.com/graftversushostdisease

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What I said was correct. MSCs don't have to be donor matched. Allogeneic MSCs have been administered to thousands of people at this point. For those who are wondering allogeneic means "not from self".

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