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NNOTM t1_ir180en wrote

Goddammit every time I read this title I think it says "drug shows mental decline"

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Shelfrock77 OP t1_ir010hw wrote

“The antibody is designed to neutralize a protein in the brain associated with the disease.”

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ZoomedAndDoomed t1_ir08i1i wrote

This almost proves that Alzheimer's is an autoimmune disease, or a disease that relates to the immune system.

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userbrn1 t1_ir1mxjl wrote

We've always known (for several decades at least I believe) that amyloid proteins contribute to Alzheimer but we still aren't sure to what degree, since it's almost certainly a multi-factorial pathology

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joe0185 t1_ir2eq5a wrote

>We've always known (for several decades at least I believe) that amyloid proteins contribute to Alzheimer

From what I understand, what we've always known is currently being called into question.

  1. A lot of the research was faked.

  2. The drug Aduhelm reduces beta-amyloid plaques in the brains of people with Alzheimer's disease but does not improve cognition nor slow progression. Which also calls into question the amyloid hypothesis.

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userbrn1 t1_ir2is90 wrote

This drug in the OP also works on AB-amyloid and does appear to slow mental decline, but it allegedly does so by inturrupting the formation of new AB-amyloid by binding its precursors rather than trying to reduce already existing amyloid plaques. If these results hold then it further strengthens the amyloid theory.

I think that first article you posted exaggerates the degree to which the research was faked; independent biochemical testing was performed by more than just the scientists in question in the article and the amyloid theory continues to prove fruitful

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