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Forgind1 OP t1_jci24g7 wrote

Should've mentioned "Gut-Derived" in the title.

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TequillaShotz t1_jciwwcz wrote

> microbiota

Which microbiota? What are the dietary implications?

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Forgind1 OP t1_jcn387a wrote

Are you asking about the abstract I put in another comment? The authors labeled Tregs in the gut and saw them appear at the site of injuries; disabling them early (by a genetic knockout or antibiotics) impeded proper healing. You can draw your own dietary conclusions, whether that be eating healthy foods or probiotics; the paper just pointed to oral antibiotics as potentially hazardous.

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TequillaShotz t1_jcu8fvk wrote

What does this mean: "microbiota-dependent Treg cells" - how do we know they are microbiota dependent? Is there any information about this? Is it merely inferred from the negative correlation to antibiotics?

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Forgind1 OP t1_jci1yv9 wrote

Specific microbial signals induce the differentiation of a distinct pool of RORγ+ regulatory T (Treg) cells crucial for intestinal homeostasis. We discovered highly analogous populations of microbiota-dependent Treg cells that promoted tissue regeneration at extra-gut sites, notably acutely injured skeletal muscle and fatty liver. Inflammatory meditators elicited by tissue damage combined with MHC-class-II-dependent T cell activation to drive the accumulation of gut-derived RORγ+ Treg cells in injured muscle, wherein they regulated the dynamics and tenor of early inflammation and helped balance the proliferation vs. differentiation of local stem cells. Reining in IL-17A-producing T cells was a major mechanism underlying the rheostatic functions of RORγ+ Treg cells in compromised tissues. Our findings highlight the importance of gut-trained Treg cell emissaries in controlling the response to sterile injury of non-mucosal tissues.

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