"In high doses" is the salient fact here.

These compounds are so small I imagine you could fill a pill with it to avoid the overwhelming sweet taste to get up to the recommended doses if it worked.

That is pretty cool, overactive immune systems can be debilitating, and these sugar substitutes are so common, and the costs are going down with use in drinks, it probably would be a pretty inexpensive intervention too.

I read through and the implication that a low-cost intervention like this would have literally ANY impact on diabetes is amazing.

From OPs reference: "The researchers did not investigate the sweetener’s effects in humans, and say that it is unlikely that normal consumption of sucralose is harmful."

1. This is a relatively naive comment and underestimates diet soda *addiction*, certainly in the US.
2. The singular conclusion that sucralose can help replace immunosuppression therapies - without addressing the obvious question, what is the effect of sucralose on the global immunosuppression of its users, seems to be a missed opportunity. It follows that we would want to understand if we have a public health issue not so much whether we have a new immunosuppression therapy.

Edit: minor grammar

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So instead of paying 1000usd per tablet of any immunosuppressive drug, just hit the 2 bottles of good old Coca-Cola.